Developing new therapies hinges on our ability to understand the cellular mechanisms that underlie diseases. Stem cells are a powerful tool for disease modelling, and in particular induced pluripotent stem cells (iPSC) are increasingly used to study the functional effects of human disease alleles. We are interested in developmental disorders that are caused by rare, loss-of-function mutations in the epigenetic machinery of the cell. Since cellular lineages from early human development are challenging to access, we use iPSCs to derive and study neuronal cell types relevant to neurodevelopmental and psychiatric disorders. We work closely with the Human Induced Pluripotent Stem Cell Initiative (HipSci) and Open Targets.